Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice

@article{Fantegrossi2003NantenineAA,
  title={Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice},
  author={W. Fantegrossi and Christina L. Kiessel and Prescott T. Leach and C Martin and Rachel Lynn Karabenick and X C Chen and Yasushi Ohizumi and Thomas Ullrich and Kenner C. Rice and James H. Woods},
  journal={Psychopharmacology},
  year={2003},
  volume={173},
  pages={270-277}
}
RationaleNo selective antagonists for the effects of MDMA have yet been identified. The structurally-similar, naturally-occurring plant alkaloid nantenine (9,10-methylenedioxy-1,2 dimethoxyaporphine) may represent such a compound.ObjectivesTo investigate the capacity of nantenine to block and/or reverse MDMA-induced hyperthermia, lethality, locomotor stimulation, and head twitches in mice, and to compare these actions with those of the selective α1 antagonist prazosin and the selective 5-HT2A… 

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