Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice

@article{Fantegrossi2003NantenineAA,
  title={Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice},
  author={W. Fantegrossi and C. L. Kiessel and P. Leach and C. Martin and Rachel Lynn Karabenick and X. Chen and Y. Ohizumi and T. Ullrich and K. Rice and J. Woods},
  journal={Psychopharmacology},
  year={2003},
  volume={173},
  pages={270-277}
}
RationaleNo selective antagonists for the effects of MDMA have yet been identified. The structurally-similar, naturally-occurring plant alkaloid nantenine (9,10-methylenedioxy-1,2 dimethoxyaporphine) may represent such a compound.ObjectivesTo investigate the capacity of nantenine to block and/or reverse MDMA-induced hyperthermia, lethality, locomotor stimulation, and head twitches in mice, and to compare these actions with those of the selective α1 antagonist prazosin and the selective 5-HT2A… Expand
Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.
The naturally occurring aporphine alkaloid nantenine, has been shown to antagonize behavioral and physiological effects of MDMA in mice. We have synthesized (+/-)-nantenine via an oxidativeExpand
Serotonin synthesis inhibition reveals distinct mechanisms of action for MDMA and its enantiomers in the mouse
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