Nanowire sensors for medicine and the life sciences.

@article{Patolsky2006NanowireSF,
  title={Nanowire sensors for medicine and the life sciences.},
  author={Fernando Patolsky and Gengfeng Zheng and Charles M. Lieber},
  journal={Nanomedicine},
  year={2006},
  volume={1 1},
  pages={
          51-65
        }
}
The interface between nanosystems and biosystems is emerging as one of the broadest and most dynamic areas of science and technology, bringing together biology, chemistry, physics and many areas of engineering, biotechnology and medicine. The combination of these diverse areas of research promises to yield revolutionary advances in healthcare, medicine and the life sciences through, for example, the creation of new and powerful tools that enable direct, sensitive and rapid analysis of… 

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References

SHOWING 1-10 OF 86 REFERENCES

Label-free detection of small-molecule-protein interactions by using nanowire nanosensors.

It is demonstrated that the silicon nanowire devices can readily and rapidly distinguish the affinities of distinct small-molecule inhibitors and, thus, could serve as a technology platform for drug discovery.

Direct ultrasensitive electrical detection of DNA and DNA sequence variations using nanowire nanosensors

Two-terminal silicon nanowire electronic devices that function as ultrasensitive and selective detectors of DNA are reported that show that detection can be carried out to at least the tens of femtomolar range.

Multiplexed electrical detection of cancer markers with nanowire sensor arrays

Highly sensitive, label-free, multiplexed electrical detection of cancer markers using silicon-nanowire field-effect devices in which distinct nanowires and surface receptors are incorporated into arrays opens up substantial possibilities for diagnosis and treatment of cancer and other complex diseases.

Nanoscale Science and Technology: Building a Big Future from Small Things

The following article is an edited transcript based on the MRS Medalist presentation given by Charles M. Lieber of Harvard University on December 4, 2002, at the Materials Research Society Fall

Seeing Within: Molecular Imaging of the Cardiovascular System

Abstract— Molecular imaging is a rapidly evolving discipline with the goal of developing tools to display and quantify molecular and cellular targets in vivo. The heart of this field is based on the

Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors

  • R. ChenS. Bangsaruntip H. Dai
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
An exploration of single-walled carbon nanotubes is presented as a platform for investigating surface–protein and protein–protein binding and developing highly specific electronic biomolecule detectors for detecting clinically important biomolecules such as antibodies associated with human autoimmune diseases.

Growth of nanowire superlattice structures for nanoscale photonics and electronics

Single-nanowire photoluminescent, electrical transport and electroluminescence measurements show the unique photonic and electronic properties of these nanowire superlattices, and suggest potential applications ranging from nano-barcodes to polarized nanoscale LEDs.

Handbook of Chemical and Biological Sensors

This handbook describes the physical and chemical principles behind sensors together with techniques for fabrication and describes the commercialization of chemical and biological sensors and the factors which must be addressed.

An investigation of the mechanisms of electronic sensing of protein adsorption on carbon nanotube devices.

  • R. ChenH. Choi H. Dai
  • Chemistry, Engineering
    Journal of the American Chemical Society
  • 2004
This work presents an elucidation of the electronic biosensing mechanisms with a newly developed microarray of nanotube "micromat" sensors and reveals that electronic effects occurring at the metal-nanotube contacts due to protein adsorption constitute a more significant contribution to the Electronic biosensing signal than adsorbed solely along the exposed lengths of the nanotubes.
...