Nanotubular Highways for Intercellular Organelle Transport

  title={Nanotubular Highways for Intercellular Organelle Transport},
  author={Amin Rustom and Rainer Saffrich and Ivanka Markovic and Paul Walther and Hans-Hermann Gerdes},
  pages={1007 - 1010}
Cell-to-cell communication is a crucial prerequisite for the development and maintenance of multicellular organisms. To date, diverse mechanisms of intercellular exchange of information have been documented, including chemical synapses, gap junctions, and plasmodesmata. Here, we describe highly sensitive nanotubular structures formed de novo between cells that create complex networks. These structures facilitate the selective transfer of membrane vesicles and organelles but seem to impede the… 

Intercellular transfer mediated by tunneling nanotubes.

Not just another hole in the wall: understanding intercellular protein trafficking.

Development and differentiation of multicellular organisms requires cell-to-cell communication. In plants direct signaling and exchange of macromolecules between cells is possible through

Intercellular nanotubes: insights from imaging studies and beyond.

These studies indicate that intercellular nanotubes may play a role both in normal physiology and in disease.

Tunneling nanotubes, an emerging intercellular communication route in development

Transfer of mitochondria and endosomes between cells by gap junction internalization

Use of three‐dimensional electron microscopy and immunogold labeling of Cx43 shows that whole organelles including mitochondria and endosomes are incorporated into double‐membrane vesicles, called connexosomes or annular gap junctions, that form as a result of gap junction internalization.

Mitochondrial Transfer by Intercellular Nanotubes

The transfer of healthy mitochondria through TNTs may rescue damaged cells and thus constitute an alternative therapeutic approach for pathologies involving oxidative stress and the importance of mitochondria transfer from stem cells to recipient cells with nonfunctional mitochondria is discussed.

Lipid nanotube networks: Biomimetic Cell-to-Cell Communication and Soft-Matter Technology

TNTs have been identified in a variety of cells, including immune cells and neurons, and have become the focus of a growing research field which generated significant results, as it became apparent that these interconnecting conduits are involved in fundamental mechanism of cell-to-cell communication.

Cellular Nanotubes: Membrane Channels for Intercellular Communication

Artificial carbon-based nanostructures with a similar architecture for communication with cells and delivery of clinically interesting drugs are developing, particularly for nano-sized materials, whose effects are yet to be thoroughly determined in vivo.

Tunneling Nanotubes: Intercellular Conduits for Direct Cell-to-Cell Communication in Cancer

This chapter discusses various concepts of intercellular communication in cancer via TNTs and highlights the potential role played by TNTs in cancer pathobiology.

Intercellular Mitochondrial Transfer in the Tumor Microenvironment

How intercellular mitochondrial transfer can be used by cancer cells to sustain their high metabolic requirements and promote drug resistance and describe relevant molecular players in the context of current and future cancer therapy are discussed.



Journey to the center of the cell: role of the receptosome.

Fibroblasts contain a specific internalization pathway that carries hormones as well as some proteins and viruses from the cell surface to the cell interior through the bristle-coated pits of the membrane.

Unconventional myosins in cell movement, membrane traffic, and signal transduction.

The task at hand is to decipher how the multitude of myosins function at both the molecular and cellular level-a task facilitated by the understanding of the myosin structure and function in muscle.

Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus

Observations suggest that phagolysosome formation is a highly dynamic process that involves the gradual and regulated acquisition of markers from endocytic organelles.

Exosome: from internal vesicle of the multivesicular body to intercellular signaling device.

F follicular dendritic cells have recently been shown to bind B-lymphocyte-derived exosome at their cell surface, which supports the notion that exosomes play an immunoregulatory role, and their molecular composition might provide clues to the mechanism of protein and lipid sorting in endosomes.

RNA as a long-distance information macromolecule in plants

A role for RNA as a non-cell-autonomous information macromolecule is emerging as a new model in biology in terms of an RNA-based signalling network that potentiates control over gene expression at the whole-plant level.

Synaptic vesicle biogenesis.

The cytoplasmic machinery of synaptic vesicle/SLMV formation and recycling has been studied by a variety of experimental approaches, in particular using cell-free systems, which revealed distinct machineries for membrane budding and fission.

Molecular engineering: Networks of nanotubes and containers

We have constructed complex two-dimensional microscopic networks of phospholipid bilayer nanotubes and containers in which we are able to control the connectivity, container size, nanotube length,

Visualization and Molecular Analysis of Actin Assembly in Living Cells

Spots, which appear as small projections on the surface by whole mount electron microscopy, represent sites of actin assembly where local and transient changes in the cortical actin cytoskeleton take place.

Intercellular movement of the putative transcription factor SHR in root patterning

It is shown that the SHR protein, a putative transcription factor, moves from the stele to a single layer of adjacent cells, where it enters the nucleus, supporting a model in which SHRprotein acts both as a signal from the Stele and as an activator of endodermal cell fate and SCR-mediated cell division.