Nanotopographical effects on mesenchymal stem cell morphology and phenotype.

  title={Nanotopographical effects on mesenchymal stem cell morphology and phenotype.},
  author={Penelope M. Tsimbouri and Nikolaj Gadegaard and Karl E V Burgess and Kate White and Paul Q Reynolds and Pawel Herzyk and Richard O C Oreffo and Matthew J. Dalby},
  journal={Journal of cellular biochemistry},
  volume={115 2},
There is a rapidly growing body of literature on the effects of topography and critically, nanotopography on cell adhesion, apoptosis and differentiation. Understanding the effects of nanotopography on cell adhesion and morphology and the consequences of cell shape changes in the nucleus, and consequently, gene expression offers new approaches to the elucidation and potential control of stem cell differentiation. In the current study we have used molecular approaches in combination with… CONTINUE READING
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