Nanotopographical cues augment mesenchymal differentiation of human embryonic stem cells.

@article{Kingham2013NanotopographicalCA,
  title={Nanotopographical cues augment mesenchymal differentiation of human embryonic stem cells.},
  author={Emmajayne Kingham and Kate White and Nikolaj Gadegaard and Matthew J. Dalby and Richard O C Oreffo},
  journal={Small},
  year={2013},
  volume={9 12},
  pages={2140-51}
}
The production of bone-forming osteogenic cells for research purposes or transplantation therapies remains a significant challenge. Using planar polycarbonate substrates lacking in topographical cues and substrates displaying a nanotopographical pattern, mesenchymal differentiation of human embryonic stem cells is directed in the absence of chemical factors and without induction of differentiation by embryoid body formation. Cells incubated on nanotopographical substrates show enhanced… CONTINUE READING

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