Nanotherapy with hybrid liposomes for colorectal cancer along with apoptosis in vitro and in vivo.

@article{Ichihara2014NanotherapyWH,
  title={Nanotherapy with hybrid liposomes for colorectal cancer along with apoptosis in vitro and in vivo.},
  author={Hideaki Ichihara and Shinichiro Nakagawa and Yusuke Matsuoka and Kenshi Yoshida and Yoko Matsumoto and Ryuichi Ueoka},
  journal={Anticancer research},
  year={2014},
  volume={34 9},
  pages={4701-8}
}
AIM We examined the therapeutic effects of hybrid liposomes (HL) composed of L-α-dimyristylphosphati-dylcholine (DMPC) and polyoxyethylene (25) dodecyl ether (C12(EO)25) on the growth of human colorectal cancer (WiDr) cells in vitro and in vivo. MATERIALS AND METHODS HL composed of 95 mol% DMPC and 5 mol% C12(EO)25 were prepared by the sonication method and their therapeutic effects in xenograft mouse models of colorectal cancer liver metastases were examined in vivo. RESULTS The inhibitory… CONTINUE READING