Nanotechnology: Peptides as biological semiconductors

  title={Nanotechnology: Peptides as biological semiconductors},
  author={Charlotte A. E. Hauser and Shuguang Zhang},
A simple peptide that assembles into desirable nanoscale structures is a striking example of how the whole can be greater than the sum of its parts. What's more, the assembly process is controllably reversible. 
Molecular self-assembly: Searching sequence space.
  • E. Gazit
  • Chemistry, Medicine
    Nature chemistry
  • 2015
A computational analysis of all 8,000 possible tripeptides has been used to identify those with interesting self-assembly behaviour.
Biomaterials: a natural source of nanowires.
Fibrous proteins from bacteria can be used to make biofilms with electrical conductivities that are comparable to those measured in conducting polymers.
Gold Nanotubes from Organic Scaffolds for Biomedical Applications
Nanoparticles are the cutting edge of the rapidly developing field of nanotechnology, which enables visualization and manipulation of matter down to the atomic level. Their unique size to volume
Peptide nanostructures: Aromatic dipeptides light up.
  • E. Gazit
  • Materials Science, Medicine
    Nature nanotechnology
  • 2016
Metal coordination and π–π stacking interactions drive the assembly of dipeptides into nanostructures with superior optical properties.
Solvent-tunable dipeptide-based nanostructures with enhanced optical-to-electrical transduction.
This work explores a facile approach to construct dipeptide-based building blocks containing π-conjugated bridges by using biocross-linkers that exhibit structure-dependent and remarkably enhanced optoelectronic properties.
Self-assembly of cyclic dipeptides: platforms for functional materials.
The progress in the design, synthesis, and characterization of cyclic dipeptide supramolecular nanomaterials over the past few decades is discussed, highlighting applications in biotechnology and optoelectronics engineering.
Nanoarchitectonics for Biology
Abstract The new elegant concept of nanoarchitectonics, which aims to construct complex functional biosystems and biodevices, has potential applications in the field of biomedicine and green energy.
Controlling molecular self-assembly: from amyloid oligomerization and therapy to novel biomaterials and technological applications in nanomedicine.
  • E. Gazit
  • Materials Science, Medicine
  • 2014
The control of molecular self-assembly at the nanoscale is a novel and promising direction for nanomedicine since many physiological and pathological processes require interactions between
Peptide-Based Hydrogels/Organogels: Assembly and Application
Peptide-based organogels/hydrogels are flexible and versatile in biological and nanotechnological applications. These supramolecular gels consisted of supramolecular fibrous networks formed through
The physical properties of supramolecular peptide assemblies: from building block association to technological applications.
The use of peptide nanostructures was indeed recently demonstrated in various fields including the design of molecular motors based on nanostructure complexation with a metal-organic framework, the delivery of therapeutic agents, the development of energy storage devices and the fabrication of piezoelectric-based sensors.


Casting Metal Nanowires Within Discrete Self-Assembled Peptide Nanotubes
The observation of the self-assembly of a very short peptide, the Alzheimer's β-amyloid diphenylalanine structural motif, into discrete and stiff nanotubes, resulted in the production of discrete nanowires with a long persistence length.
Self-assembled peptide nanotubes are uniquely rigid bioinspired supramolecular structures.
This work finds that the averaged point stiffness of the nanotubes is 160 N/m, and that they have a correspondingly high Young's modulus of approximately 19 GPa, as calculated by finite element analysis.
Elementary building blocks of self-assembled peptide nanotubes.
An exceptional quantum-confined approach is shown here for the self-assembly mechanism in bio-inspired materials, finding the elementary building block of the studied PNT, which is self-assembled from short peptides composed of two phenylalanine residues, to be 0D-quantum-confinement, also called a quantum dot (QD).
Quantum confinement in self-assembled bioinspired peptide hydrogels.
This work examined the optical properties, optical absorption and photoluminescence of hydrogels that were self-assembled from Fmoc-FF building blocks, and followed the formation of a quantum confined structure within the hydrogel nanotubes.
Strong piezoelectricity in bioinspired peptide nanotubes.
Anomalously strong shear piezoelectric activity in self-assembled diphenylalanine peptide nanotubes (PNTs) is shown, indicating electric polarization directed along the tube axis, opening up a wide avenue for developing new generations of "green" piezOElectric materials and piezonanodevices based on bioactive tubular nanostructures potentially compatible with human tissue.
Blue luminescence based on quantum confinement at peptide nanotubes.
The estimations show that QC in these nanotubes occurs due to a crystalline structure of subnanometer scale dimension formed under the self-assembly process, paving the way for the integration of PNT in a new generation of optical devices.