Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems

  title={Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems},
  author={Sha-sha Guan and Josef Rosenecker},
  journal={Gene Therapy},
Because of its safe and effective protein expression profile, in vitro transcribed messenger RNA (IVT-mRNA) represents a promising candidate in the development of novel therapeutics for genetic diseases, vaccines or gene editing strategies, especially when its inherent shortcomings (for example, instability and immunogenicity) have been partially addressed via structural modifications. However, numerous unsolved technical difficulties in successful in vivo delivery of IVT-mRNA have greatly… CONTINUE READING
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