Nanostructured lipid carrier (NLC) coated with Chitosan Oligosaccharides and its potential use in ocular drug delivery system.

@article{Luo2011NanostructuredLC,
  title={Nanostructured lipid carrier (NLC) coated with Chitosan Oligosaccharides and its potential use in ocular drug delivery system.},
  author={Qiuhua Luo and Junming Zhao and Xiangrong Zhang and Weisan Pan},
  journal={International journal of pharmaceutics},
  year={2011},
  volume={403 1-2},
  pages={185-91}
}
The objective of the present investigation was to explore the potential of the Chitosan Oligosaccharides (COS)-coated NLC (nanostructured lipid carrier) for ocular drug delivery. NLC loaded with flurbiprofen was prepared by melt-ultrasonic method and then coated with COS with a molecular weight of 3000-6000kDa. After coating, the particles reflected spherical morphology with smooth surface under transmission electron microscope (TEM) analysis and a changed zeta potential from -0.446mV to +20… CONTINUE READING