Nanostructure-initiator mass spectrometry: a protocol for preparing and applying NIMS surfaces for high-sensitivity mass analysis

@article{Woo2008NanostructureinitiatorMS,
  title={Nanostructure-initiator mass spectrometry: a protocol for preparing and applying NIMS surfaces for high-sensitivity mass analysis},
  author={H. Woo and Trent R. Northen and {\'O}. Yanes and G. Siuzdak},
  journal={Nature Protocols},
  year={2008},
  volume={3},
  pages={1341-1349}
}
  • H. Woo, Trent R. Northen, +1 author G. Siuzdak
  • Published 2008
  • Materials Science, Medicine
  • Nature Protocols
  • Nanostructure-initiator mass spectrometry (NIMS) is a new surface-based MS technique that uses a nanostructured surface to trap liquid ('initiator') compounds. Analyte materials adsorbed onto this 'clathrate' surface are subsequently released by laser irradiation for mass analysis. In this protocol, we describe the preparation of NIMS surfaces capable of producing low background and high-sensitivity mass spectrometric measurement using the initiator compound BisF17. Examples of analytes that… CONTINUE READING
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