Nanosize and vitality: TiO2 nanotube diameter directs cell fate.

  title={Nanosize and vitality: TiO2 nanotube diameter directs cell fate.},
  author={Jung Ju Park and Sebastian Bauer and Klaus von der Mark and Patrik Schmuki},
  journal={Nano letters},
  volume={7 6},
We generated, on titanium surfaces, self-assembled layers of vertically oriented TiO2 nanotubes with defined diameters between 15 and 100 nm and show that adhesion, spreading, growth, and differentiation of mesenchymal stem cells are critically dependent on the tube diameter. A spacing less than 30 nm with a maximum at 15 nm provided an effective length scale for accelerated integrin clustering/focal contact formation and strongly enhances cellular activities compared to smooth TiO2 surfaces… CONTINUE READING
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