Nanosecond temperature jump relaxation dynamics of cyclic beta-hairpin peptides.

  title={Nanosecond temperature jump relaxation dynamics of cyclic beta-hairpin peptides.},
  author={Shelia J. Maness and Stefan Franzen and Alan C. Gibbs and Timothy P. Causgrove and R. Brian Dyer},
  journal={Biophysical journal},
  volume={84 6},
The thermal unfolding of a series of 6-, 10-, and 14-mer cyclic beta-hairpin peptides was studied to gain insight into the mechanism of formation of this important secondary structure. The thermodynamics of the transition were characterized using temperature dependent Fourier transform infrared spectroscopy. Thermodynamic data were analyzed using a two-state model which indicates increasing cooperativity along the series. The relaxation kinetics of the peptides in response to a laser induced… CONTINUE READING


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