Nanosecond pulsed electric fields stimulate apoptosis without release of pro-apoptotic factors from mitochondria in B16f10 melanoma.

@article{Ford2010NanosecondPE,
  title={Nanosecond pulsed electric fields stimulate apoptosis without release of pro-apoptotic factors from mitochondria in B16f10 melanoma.},
  author={Wentia E. Ford and Wei Ren and Peter F. Blackmore and Karl H. Schoenbach and Stephen J. Beebe},
  journal={Archives of biochemistry and biophysics},
  year={2010},
  volume={497 1-2},
  pages={82-9}
}
Nanosecond pulsed electric fields (nsPEFs) eliminates B16f10 melanoma in mice, but cell death mechanisms and kinetics of molecular events of cell death are not fully characterized. Treatment of B16f10 cells in vitro resulted in coordinate increases in active caspases with YO-PRO-1 uptake, calcium mobilization, decreases in mitochondria membrane potential with decreases in forward light scatter (cell size), increases in ADP/ATP ratio, degradation of actin cytoskeleton and membrane blebbing… CONTINUE READING
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