Nanosecond, high‐intensity pulsed electric fields induce apoptosis in human cells

  title={Nanosecond, high‐intensity pulsed electric fields induce apoptosis in human cells},
  author={Stephen J. Beebe and Paula M. Fox and Laura J. Rec and Lauren K. Willis and Karl H. Schoenbach},
  journal={The FASEB Journal},
  • Stephen J. Beebe, Paula M. Fox, +2 authors Karl H. Schoenbach
  • Published 2003
  • Biology, Medicine
  • The FASEB Journal
  • Electroporation by using pulsed electric fields with long durations compared with the charging time of the plasma membrane can induce cell fusion or introduce xenomolecules into cells. Nanosecond pulse power technology generates pulses with high‐intensity electric fields, but with such short durations that the charging time of the plasma membrane is not reached, but intracellular membranes are affected. To determine more specifically their effects on cell structure and function, human cells… CONTINUE READING
    378 Citations
    Leukemic cell intracellular responses to nanosecond electric fields.
    • 122
    Diverse effects of nanosecond pulsed electric fields on cells and tissues.
    • 209
    • Highly Influenced
    Nanosecond Pulsed Electric Fields Induce a Mitochondria-Independent Apoptosis in B16F10 Melanoma Cells In Vitro
    Dynamic effects and applications for nanosecond pulsed electric fields in cells and tissues
    Dependence on pulse duration and number of tumor cell apoptosis by nanosecond pulsed electric fields
    • 6
    Two Modes of Cell Death Caused by Exposure to Nanosecond Pulsed Electric Field
    • 70
    • PDF
    Calcium bursts induced by nanosecond electric pulses.
    • 343


    Nanosecond pulsed electric field (nsPEF) effects on cells and tissues: apoptosis induction and tumor growth inhibition
    • 366
    Electric Field Pulses Can Induce Apoptosis
    • 76
    Intracellular effect of ultrashort electrical pulses.
    • 463
    • Highly Influential
    Fundamentals of electroporative delivery of drugs and genes.
    • 374
    Apoptosis induced by DNA uptake limits transfection efficiency.
    • 52