Nanoscale structure-activity relationships, mode of action, and biocompatibility of gold nanoparticle antibiotics.

@article{Bresee2014NanoscaleSR,
  title={Nanoscale structure-activity relationships, mode of action, and biocompatibility of gold nanoparticle antibiotics.},
  author={Jamee Bresee and Constance Marie Bond and Roberta J. Worthington and Candice A Smith and Jennifer C. Gifford and Carrie A. Simpson and Carly J. Carter and Guankui Wang and Jesse G. N. Hartman and Niki A. Osbaugh and Richard K Shoemaker and Christian Melander and Daniel L. Feldheim},
  journal={Journal of the American Chemical Society},
  year={2014},
  volume={136 14},
  pages={
          5295-300
        }
}
The emergence of resistance to multiple antimicrobial agents by pathogenic bacteria has become a significant global public health threat. Multi-drug-resistant (MDR) Gram-negative bacteria have become particularly problematic, as no new classes of small-molecule antibiotics for Gram-negative bacteria have emerged in over two decades. We have developed a combinatorial screening process for identifying mixed ligand monolayer/gold nanoparticle conjugates (2.4 nm diameter) with antibiotic activity… 
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