Nanoscale positioning of individual DNA molecules by an atomic force microscope.

@article{Josephs2010NanoscalePO,
  title={Nanoscale positioning of individual DNA molecules by an atomic force microscope.},
  author={Eric A. Josephs and Tao Ye},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 30},
  pages={10236-8}
}
Here we report a method to assemble nanoscale DNA structures with single-molecule precision. This assembly is accomplished by performing nanografting in the presence of short, thiolated DNA strands that have been diluted by a positively charged alkanethiol. The expected number of DNA molecules per patch can be modulated by the application of an electric potential to the surface during patterning. Our ability to position individual DNA within a controlled nanoscale environment and observe these… CONTINUE READING