Nanoscale organization of the pathogen receptor DC-SIGN mapped by single-molecule high-resolution fluorescence microscopy.

@article{Bakker2007NanoscaleOO,
  title={Nanoscale organization of the pathogen receptor DC-SIGN mapped by single-molecule high-resolution fluorescence microscopy.},
  author={B{\"a}rbel I. de Bakker and Frank de Lange and Alessandra Cambi and Jeroen P. Korterik and Erik M.H.P. van Dijk and Niek F van Hulst and Carl Gustav Figdor and Mar{\'i}a F Garc{\'i}a-Parajo},
  journal={Chemphyschem : a European journal of chemical physics and physical chemistry},
  year={2007},
  volume={8 10},
  pages={
          1473-80
        }
}
DC-SIGN, a C-type lectin exclusively expressed on dendritic cells (DCs), plays an important role in pathogen recognition by binding with high affinity to a large variety of microorganisms. Recent experimental evidence points to a direct relation between the function of DC-SIGN as a viral receptor and its spatial arrangement on the plasma membrane. We have investigated the nanoscale organization of fluorescently labeled DC-SIGN on intact isolated DCs by means of near-field scanning optical… CONTINUE READING
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