Nanoscale mechanics guides cellular decision making.

Abstract

This study used novel, force-limited nanoscale tension gauges to investigate how force and substrate stiffness guide cellular decision-making during initial cell attachment and spreading on deformable substrates. The well-established dependence of cell traction and spreading on substrate stiffness has been attributed to levels of force exerted on molecular… (More)
DOI: 10.1039/c6ib00113k

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