Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer’s-Associated Aβ Oligomers

@inproceedings{Wilcox2015NanoscaleSM,
  title={Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer’s-Associated Aβ Oligomers},
  author={Kyle C. Wilcox and Matthew R. Marunde and Aditi Das and Pauline T. Velasco and Benjamin D. Kuhns and Michael T Marty and Haoming Jiang and Chi-Hao Luan and Stephen G Sligar and William L. Klein},
  booktitle={PloS one},
  year={2015}
}
Despite their value as sources of therapeutic drug targets, membrane proteomes are largely inaccessible to high-throughput screening (HTS) tools designed for soluble proteins. An important example comprises the membrane proteins that bind amyloid β oligomers (AβOs). AβOs are neurotoxic ligands thought to instigate the synapse damage that leads to Alzheimer's dementia. At present, the identities of initial AβO binding sites are highly uncertain, largely because of extensive protein-protein… CONTINUE READING
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Brain Transit and Ameliorative Effects of Intranasally Delivered Anti - Amyloid - beta Oligomer Antibody in 5 XFADMice

  • C Xiao, FJ Davis, BC Chauhan, KL Viola, PN Lacor, PT Velasco
  • Journal of Alzheimer ' s disease : JAD
  • 2013

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