Nanoscale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain

@inproceedings{Cheng2016NanoscalePM,
  title={Nanoscale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain},
  author={Hank Cheng and Arian Saffari and Constantinos Sioutas and Henry Jay Forman and Todd E Morgan and Caleb E. Finch},
  booktitle={Environmental health perspectives},
  year={2016}
}
BACKGROUND Rodent models for urban air pollution show consistent induction of inflammatory responses in major brain regions. However, the initial impact of air pollution particulate material on olfactory gateways has not been reported. OBJECTIVE We evaluated the olfactory neuroepithelium (OE) and brain regional responses to a nanosized subfraction of urban traffic ultrafine particulate matter (nPM, < 200 nm) in vivo, ex vivo, and in vitro. METHODS Adult mice were exposed to reaerosolized… CONTINUE READING
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