Nanoprodrugs of NSAIDs: Preparation and Characterization of Flufenamic Acid Nanoprodrugs

@inproceedings{Lee2011NanoprodrugsON,
  title={Nanoprodrugs of NSAIDs: Preparation and Characterization of Flufenamic Acid Nanoprodrugs},
  author={B L Lee and Chi Woo Yoon and Arsen Osipov and Nuriel Moghavem and Daniel Nwachokor and Rina Amatya and Rebekah Na and Joe L. Pantoja and Michael D. Pham and Keith L. Black and Jeffrey Yu},
  booktitle={Journal of drug delivery},
  year={2011}
}
We demonstrated that hydrophobic derivatives of the nonsteroidal anti-inflammatory drug (NSAID)flufenamic acid (FA), can be formed into stable nanometer-sized prodrugs (nanoprodrugs) that inhibit the growth of glioma cells, suggesting their potential application as anticancer agent. We synthesized highly hydrophobic monomeric and dimeric prodrugs of FA via esterification and prepared nanoprodrugs using spontaneous emulsification mechanism. The nanoprodrugs were in the size range of 120 to 140… CONTINUE READING

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