Nanoporous materials for biomedical devices

  title={Nanoporous materials for biomedical devices},
  author={Shashishekar P. Adiga and Larry A. Curtiss and Jeffrey W. Elam and Michael J Pellin and Chun Che Shih and Chun Ming Shih and Shing‐Jong Lin and Yea‐Yang Su and Shaun Davis Gittard and Junping Zhang and Roger J. Narayan},
Nanoporous materials are currently being developed for use in implantable drug delivery systems, bioartificial organs, and other novel medical devices. Advances in nanofabrication have made it possible to precisely control the pore size, pore distribution, porosity, and chemical properties of pores in nanoporous materials. As a result, these materials are attractive for regulating and sensing transport at the molecular level. In this work, the use of nanoporous membranes for biomedical… 
Nanoporous membranes for medical and biological applications.
An overview of nanoporous membranes for biomedical applications, including biosensing, biosorting, immunoisolation, and drug delivery, are presented and desirable properties of membranes used in implantable devices, including biocompatibility and antibiofouling behavior are discussed.
Atomic layer deposition-based functionalization of materials for medical and environmental health applications
  • R. Narayan, S. P. Adiga, J. Elam
  • Chemistry
    Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
  • 2010
The results of this work indicate that nanoporous alumina membranes may be modified using atomic layer deposition for use in a variety of medical and environmental health applications.
Stimuli-Responsive Polymer Brushes for Flow Control through Nanopores
In this work, an overview of nanoporous materials functionalized with responsive polymers is given and a theoretical treatment that accounts for polymer conformational change in response to a stimulus and the associated flow-control effect is presented.
Potential Application of Nanoporous Materials in Biomedical Field
Nanoporous materials are the substances having pores of size 100 nanometers in a frame work organic or inorganic substance. These substances are used in medical devices such as bioartificial organ
Nanopore Technology
  • N. Khan
  • Biology, Chemistry
    International Journal of Clinical and Experimental Medicine Research
  • 2021
Nanopore technology in DNA sequencing provides a good representation of present-day advancement in biochemical molecular techniques, and can revolutionize the therapeutic companies.
Nanoscale porosity in polymer films: fabrication and therapeutic applications.
This review focuses on current developments in the field of nanostructured bulk polymers and their application in bioengineering and therapeutic sciences, and contemporary fabrication and processing techniques capable of producing nanoporous polymer films are reviewed.
Design of nanoporous materials with optimal sorption capacity
Modern technological advances have enabled one to manufacture nanoporous materials with a prescribed pore structure. This raises a possibility of using controllable pore-scale parameters (e.g., pore


Nanoporous hard carbon membranes for medical applications.
The diamondlike carbon-coated anodized aluminum oxide membranes remained free from protein adsorption during in vitro platelet rich plasma testing and are anticipate that this novel membrane could find use in immunoisolation devices, pacemakers, kidney dialysis membranes, microdialysis systems, and other devices facing biocompatibility issues that limit in vivo function.
Small-scale systems for in vivo drug delivery
Micro- and nanotechnologies are enabling the design of novel methods such as radio-frequency addressing of individual molecules or the suppression of immune response to a release device, but current challenges include the need to balance the small scale of the devices with the quantities of drugs that are clinically necessary.
Hybrid Bioinorganic Smart Membranes That Incorporate Protein-Based Molecular Switches
It is demonstrated here that the LCST behavior of ELPs can be retained when they are entrapped in hydrated silica gels and that theLCST transition of these molecules can be used to toggle the permeability of hybrid membranes.
Charge- and size-based separation of macromolecules using ultrathin silicon membranes
The development of an ultrathin porous nanocrystalline silicon (pnc-Si) membrane is reported using straightforward silicon fabrication techniques that provide control over average pore sizes from approximately 5 nm to 25’nm, expected to enable a variety of new devices, including membrane-based chromatography systems and both analytical and preparative microfluidic systems that require highly efficient separations.
Tailoring width of microfabricated nanochannels to solute size can be used to control diffusion kinetics.
  • F. Martin, R. Walczak, M. Ferrari
  • Biology, Engineering
    Journal of controlled release : official journal of the Controlled Release Society
  • 2005
Characterization of Nanoporous Membranes for Immunoisolation: Diffusion Properties and Tissue Effects
In this study, diffusion of biologically relevant molecules through the microfabricated membrane was characterized using a two-compartment diffusion chamber and, to improve in vivo long term diffusion performance, biocapsules were implanted in animals and the degree of foreign body response was assessed.
Nanostructured antifouling poly(ethylene glycol) films for silicon-based microsystems.
PEG thin films formed by using higher PEG concentrations or coupling time demonstrated enhanced protein fouling resistance behavior, and this analysis is expected to be useful to form PEG films of desired grafting density on silicon substrates for appropriate application.
Nanoporous Alumina Membranes for Enhancing Hemodialysis
The nonuniformity of pore size and pore distribution of the current hemodialysis membrane results in low efficiency of uremic solute removal as well as the loss of albumin. By using nanotechnology,
A pH‐Responsive Gating Membrane System with Pumping Effects for Improved Controlled Release
In this study, we report on a novel composite membrane system for pH‐responsive controlled release, which is composed of a porous membrane with linear grafted, positively pH‐responsive polymeric
Fast fabrication of long-range ordered porous alumina membranes by hard anodization
A new oxalic-acid-based anodization process for long-range ordered alumina membranes that establishes a new self-ordering regime with interpore distances, (Dint)=200–300 nm, allowing 2,500–3,500% faster oxide growth with improved ordering of the nanopores.