Nanopore-spanning lipid bilayers on silicon nitride membranes that seal and selectively transport ions.

  title={Nanopore-spanning lipid bilayers on silicon nitride membranes that seal and selectively transport ions.},
  author={Christopher E Korman and Mischa Megens and Caroline M Ajo-Franklin and David A. Horsley},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  volume={29 14},
We report the formation of POPC lipid bilayers that span 130 nm pores in a freestanding silicon nitride film supported on a silicon substrate. These solvent-free lipid membranes self-assemble on organosilane-treated Si3N4 via the fusion of 200 nm unilamellar vesicles. Membrane fluidity is verified by fluorescence recovery after photobleaching (FRAP), and membrane resistance in excess of 1 GΩ is demonstrated using electrical impedance spectroscopy (EIS). An array of 40,000 membranes maintained… CONTINUE READING
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