Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection.

@article{Cao2002NanoparticlesWR,
  title={Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection.},
  author={Y. Charles Cao and Rongchao Jin and Chad A. Mirkin},
  journal={Science},
  year={2002},
  volume={297 5586},
  pages={1536-40}
}
Multiplexed detection of oligonucleotide targets has been performed with gold nanoparticle probes labeled with oligonucleotides and Raman-active dyes. The gold nanoparticles facilitate the formation of a silver coating that acts as a surface-enhanced Raman scattering promoter for the dye-labeled particles that have been captured by target molecules and an underlying chip in microarray format. The strategy provides the high-sensitivity and high-selectivity attributes of gray-scale scanometric… CONTINUE READING

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