Nanoparticles sustain expression of Flt intraceptors in the cornea and inhibit injury-induced corneal angiogenesis.

@article{Jani2007NanoparticlesSE,
  title={Nanoparticles sustain expression of Flt intraceptors in the cornea and inhibit injury-induced corneal angiogenesis.},
  author={Pooja D. Jani and Nirbhai Singh and Crystal L Jenkins and Swita Raghava and Yun Mo and Shivan H. Amin and Uday B. Kompella and Balamurali Krishna Ambati},
  journal={Investigative ophthalmology & visual science},
  year={2007},
  volume={48 5},
  pages={2030-6}
}
PURPOSE To determine whether long-term expression of intraceptors can be achieved using plasmid albumin nanoparticles and whether nanoparticles can inhibit and cause regression of murine corneal neovascularization induced by mechanical-chemical trauma. METHODS Albumin nanoparticles encapsulating pCMV.Flt23K were developed as a lyophilized product that is easily redispersed in an aqueous medium. Nanoparticles were injected into the corneas of uninjured BALB/c mice and observed for toxicity for… CONTINUE READING
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