Nanoparticles of glycol chitosan and its thiolated derivative significantly improved the pulmonary delivery of calcitonin.

@article{Makhlof2010NanoparticlesOG,
  title={Nanoparticles of glycol chitosan and its thiolated derivative significantly improved the pulmonary delivery of calcitonin.},
  author={Abdallah Makhlof and Martin Werle and Yuichi Tozuka and Hirofumi Takeuchi},
  journal={International journal of pharmaceutics},
  year={2010},
  volume={397 1-2},
  pages={92-5}
}
A novel thiomer derivative of glycol chitosan (GCS) was synthesized by coupling with thioglycolic acid (TGA) and evaluated for the pulmonary delivery of peptides. Nanoparticles (NPs) based on GCS and GCS-TGA were obtained by the ionic gelation method and demonstrated a particle size in the range of 0.23-0.33 microm with positive surface charge and high calcitonin entrapment. Fluorescent GCS-TGA NPs resulted in a 2-fold increase in mucoadhesion to lung tissue after intra-tracheal administration… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Improve - ment of the pulmonary absorption of ( Asu 1 , 7 )eel calcitonin by various protease inhibitors in rats

  • J. S. Patton, P. Trinchero, R. M. Platz
  • Pharm Res .
  • 1994
Highly Influential
1 Excerpt

The potential of glycol chitosan nanoparticles as carrier for low water soluble drugs

  • A. Weissenböck, M. Wirth, F. Gabor
  • Int . J . Pharm .
  • 2009

A comparison of the pulmonary bioavailability of powder and liquid aerosol formulations of salmon calcitonin

  • A. lark, M. Kuo, S. Newman, P. Hirst, G. Pitacairn, M. Pickford
  • Pharm . Res .
  • 2008

Inhalednanoparticles – a current review

  • Y. S. Youn, M. J. Kwon, D. H. Na, S. Y. Chae, S. Lee, K. C. Lee
  • Int . J . Pharm .
  • 2008
1 Excerpt

Similar Papers

Loading similar papers…