Nanoparticles laden in situ gel of levofloxacin for enhanced ocular retention.

@article{Gupta2013NanoparticlesLI,
  title={Nanoparticles laden in situ gel of levofloxacin for enhanced ocular retention.},
  author={Himanshu Gupta and Mohammed Aqil and Roop Krishen Khar and Asgar Ali and Aseem Bhatnagar and Gaurav Mittal},
  journal={Drug delivery},
  year={2013},
  volume={20 7},
  pages={306-9}
}
Availability of proper concentration of medicament on to the corneal surface is a challenging task. Many novel formulations, i.e. hydrogels, nanoparticles, ocuserts, etc. had been tested to improve ocular bioavailability, out of which our group found, in situ gel and polymeric nanoparticle are the most interesting approach to achieve ocular retention. We found that in situ gel stay only for 12 h and poly(lactic-co-glycolic acid (PLGA) nanoparticles are non mucoadhesive in nature so we try to… CONTINUE READING