Nanoparticles for transcutaneous vaccination

  title={Nanoparticles for transcutaneous vaccination},
  author={Steffi Hansen and Claus‐Michael Lehr},
  booktitle={Microbial biotechnology},
The living epidermis and dermis are rich in antigen presenting cells (APCs). Their activation can elicit a strong humoral and cellular immune response as well as mucosal immunity. Therefore, the skin is a very attractive site for vaccination, and an intradermal application of antigen may be much more effective than a subcutaneous or intramuscular injection. However, the stratum corneum (SC) is a most effective barrier against the invasion of topically applied vaccines. Products which have… CONTINUE READING