Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications

@article{Accardo2011NanoparticlesCO,
  title={Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications},
  author={A. Accardo and Anna Morisco and E. Gianolio and D. Tesauro and G. Mangiapia and A. Radulescu and A. Brandt and G. Morelli},
  journal={Journal of Peptide Science},
  year={2011},
  volume={17}
}
New mixed nanoparticles were obtained by self‐aggregation of two amphiplic monomers. The first monomer (C18)2L5‐Oct contains two C18 hydrophobic moieties bound to the N‐terminus of the cyclic peptide octreotide, and spaced from the bioactive peptide by five units of dioxoethylene linkers. The second monomer, (C18)2DTPAGlu, (C18)2DTPA or (C18)2DOTA, and the corresponding Gd(III) complexes, contains two C18 hydrophobic moieties bound through a lysine residue to different polyamino‐polycarboxy… Expand
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