Nanoparticles Based on a Hydrophilic Polyester with a Sheddable PEG Coating for Protein Delivery

@article{Samadi2014NanoparticlesBO,
  title={Nanoparticles Based on a Hydrophilic Polyester with a Sheddable PEG Coating for Protein Delivery},
  author={Neda Samadi and Mies J. van Steenbergen and Joep B. van den Dikkenberg and Tina Vermonden and Cornelus F. van Nostrum and Maryam Amidi and Wim E Hennink},
  journal={Pharmaceutical Research},
  year={2014},
  volume={31},
  pages={2593-2604}
}
To investigate the effect of polyethylene glycol (PEG) in nanoparticles based on blends of hydroxylated aliphatic polyester, poly(D,L-lactic-co-glycolic-co-hydroxymethyl glycolic acid) (PLGHMGA) and PEG-PLGHMGA block copolymers on their degradation and release behavior. Protein-loaded nanoparticles were prepared with blends of varying ratios of PEG-PLGHMGA… CONTINUE READING