Nanoparticle strategies for enhancing the sensitivity of fluorescence-based biochips.

@article{McDonagh2009NanoparticleSF,
  title={Nanoparticle strategies for enhancing the sensitivity of fluorescence-based biochips.},
  author={Colette McDonagh and Ondrej Stranik and Robert Nooney and Brian D. MacCraith},
  journal={Nanomedicine},
  year={2009},
  volume={4 6},
  pages={645-56}
}
This article describes strategies for achieving fluorescence enhancement in optical biochips. Two strategies are discussed: plasmonic enhancement, which is due to the localized surface plasmon resonance of metal nanostructures that are adjacent to the fluorescent labels in optical immunoassays; and the use of high-brightness silica nanoparticles as enhanced labels. We present a review of the state-of-the-art in both areas, including synthesis techniques for the metal and silica nanoparticles… CONTINUE READING