Nanoparticle stability in biologically relevant media: influence of polymer architecture.

@article{AguilarCastillo2015NanoparticleSI,
  title={Nanoparticle stability in biologically relevant media: influence of polymer architecture.},
  author={Bethsy Adriana Aguilar-Castillo and Jos{\'e} Lu{\'i}s Santos and Hanying Luo and Yanet E Aguirre-Chagala and Teresa Palacios-Hern{\'a}ndez and Margarita Herrera-Alonso},
  journal={Soft matter},
  year={2015},
  volume={11 37},
  pages={7296-307}
}
We have contrasted the behavior of nanoparticles formed by the self-assembly of polymers based on poly(ethylene glycol) (PEG) and poly(D,L-lactide), with linear, linear-dendritic and bottle-brush architectures in biologically relevant media. Polymer PEG content ranged between 14% and 46% w/w, and self-assembly was triggered by a rapid and large change in solvent quality inside a four-stream vortex mixer. We examined nanoparticle interaction with human serum albumin (HSA), and solute release in… CONTINUE READING