Nanoparticle size is a critical physicochemical determinant of the human blood plasma corona: a comprehensive quantitative proteomic analysis.

@article{Tenzer2011NanoparticleSI,
  title={Nanoparticle size is a critical physicochemical determinant of the human blood plasma corona: a comprehensive quantitative proteomic analysis.},
  author={Stefan Tenzer and Dominic Docter and Susanne Rosfa and Alexandra Wlodarski and J{\"o}rg Kuharev and Alexander Rekik and Shirley K. Knauer and Christoph Bantz and Thomas Nawroth and Carolin Bier and Jarinratn Sirirattanapan and Wolf Mann and Lennart Treuel and Reinhard Zellner and Michael Maskos and Hansjoerg Schild and Roland H. Stauber},
  journal={ACS nano},
  year={2011},
  volume={5 9},
  pages={7155-67}
}
In biological fluids, proteins associate with nanoparticles, leading to a protein "corona" defining the biological identity of the particle. However, a comprehensive knowledge of particle-guided protein fingerprints and their dependence on nanomaterial properties is incomplete. We studied the long-lived ("hard") blood plasma derived corona on monodispersed amorphous silica nanoparticles differing in size (20, 30, and 100 nm). Employing label-free liquid chromatography mass spectrometry, one… CONTINUE READING