Nanoparticle-mediated wild-type p53 gene delivery results in sustained antiproliferative activity in breast cancer cells.

@article{Prabha2004NanoparticlemediatedWP,
  title={Nanoparticle-mediated wild-type p53 gene delivery results in sustained antiproliferative activity in breast cancer cells.},
  author={S. P Shaji Prabha and Vinod Labhasetwar},
  journal={Molecular pharmaceutics},
  year={2004},
  volume={1 3},
  pages={211-9}
}
Gene expression with nonviral vectors is usually transient and lasts for only a few days. Therefore, repeated injection of the expression vector is required to maintain a therapeutic protein concentration in the target tissue. Biodegradable nanoparticles (approximately 200 nm diameter) formulated using a biocompatible polymer, poly(D,L-lactide-co-glycolide) (PLGA), have the potential for sustained gene delivery. Our hypothesis is that nanoparticle-mediated gene delivery would result in… CONTINUE READING