Nanoparticle-mediated cellular response is size-dependent.

  title={Nanoparticle-mediated cellular response is size-dependent.},
  author={Wen Jiang and Betty Y S Kim and James T. Rutka and Warren W C Chan},
  journal={Nature nanotechnology},
  volume={3 3},
Nanostructures of different sizes, shapes and material properties have many applications in biomedical imaging, clinical diagnostics and therapeutics. In spite of what has been achieved so far, a complete understanding of how cells interact with nanostructures of well-defined sizes, at the molecular level, remains poorly understood. Here we show that gold and silver nanoparticles coated with antibodies can regulate the process of membrane receptor internalization. The binding and activation of… CONTINUE READING
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