Nanoparticle-macrophage interactions: A balance between clearance and cell-specific targeting.

  title={Nanoparticle-macrophage interactions: A balance between clearance and cell-specific targeting.},
  author={Rahul Rattan and Somnath Bhattacharjee and Hong R. Zong and Corban Swain and Muneeb A Siddiqui and Scott H Visovatti and Yogendra Kanthi and Sajani Desai and David J. Pinsky and Sascha N. Goonewardena},
  journal={Bioorganic & medicinal chemistry},
  volume={25 16},
The surface properties of nanoparticles (NPs) are a major factor that influences how these nanomaterials interact with biological systems. Interactions between NPs and macrophages of the reticuloendothelial system (RES) can reduce the efficacy of NP diagnostics and therapeutics. Traditionally, to limit NP clearance by the RES system, the NP surface is neutralized with molecules like poly(ethylene glycol) (PEG) which are known to resist protein adsorption and RES clearance. Unfortunately, PEG… CONTINUE READING