Nanoparticle hydrophobicity dictates immune response.

@article{Moyano2012NanoparticleHD,
  title={Nanoparticle hydrophobicity dictates immune response.},
  author={Daniel F. Moyano and Meir Goldsmith and David J. Solfiell and Dalit Landesman-Milo and Oscar R. Miranda and D. Peer and V. Rotello},
  journal={Journal of the American Chemical Society},
  year={2012},
  volume={134 9},
  pages={
          3965-7
        }
}
  • Daniel F. Moyano, Meir Goldsmith, +4 authors V. Rotello
  • Published 2012
  • Medicine, Chemistry
  • Journal of the American Chemical Society
  • Understanding the interactions of nanomaterials with the immune system is essential for the engineering of new macromolecular systems for in vivo applications. Systematic study of immune activation is challenging due to the complex structure of most macromolecular probes. We present here the use of engineered gold nanoparticles to determine the sole effect of hydrophobicity on the immune response of splenocytes. The gene expression profile of a range of cytokines (immunological reporters) was… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 41 REFERENCES
    Effect of surface properties on nanoparticle-cell interactions.
    • 1,730
    Innate immune recognition.
    • 7,384
    • Open Access
    Using nano-QSAR to predict the cytotoxicity of metal oxide nanoparticles.
    • 443
    • Open Access
    Toll-like receptor signalling
    • 7,234
    Regulation of Adaptive Immunity by the Innate Immune System
    • 1,699
    • Open Access