Nanoparticle encapsulated antitubercular drugs as a potential oral drug delivery system against murine tuberculosis.

@article{Pandey2003NanoparticleEA,
  title={Nanoparticle encapsulated antitubercular drugs as a potential oral drug delivery system against murine tuberculosis.},
  author={Rajesh Kumar Pandey and Arshad Zahoor and Sadhna Sharma and Gopal Krishan Khuller},
  journal={Tuberculosis},
  year={2003},
  volume={83 6},
  pages={373-8}
}
Patient non-compliance is the major drawback associated with the long-duration chemotherapy of tuberculosis (TB); hence, reduction in dosing frequency forms an important therapeutic strategy. The present study reports the formulation of three frontline antitubercular drugs (ATD), i.e. rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA) encapsulated in poly (DL-lactide-co-glycolide) (PLG) nanoparticles. Drug encapsulation efficiencies were 56.9+/-2.7% for RIF, 66.3+/-5.8% for INH and 68+/-5… CONTINUE READING

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