Nanoparticle drug delivery systems: an excellent carrier for tumor peptide vaccines

@article{Wang2018NanoparticleDD,
  title={Nanoparticle drug delivery systems: an excellent carrier for tumor peptide vaccines},
  author={Jiemin Wang and Xiong-Bin Hu and Daxiong Xiang},
  journal={Drug Delivery},
  year={2018},
  volume={25},
  pages={1319 - 1327}
}
Abstract In the past 40 years, the nanoparticle drug delivery system for tumor peptide vaccines has been widely studied which also reached a splendid result. Nanomaterial can enhance the targeting of vaccines, help vaccines enter the cells and trigger immune response by themselves. They also help in increasing cellular uptake, improving permeability and efficacy. Currently, several categories of nanopreparation, such as liposome, polymeric micelle, polymeric nanoparticle, gold nanoparticle and… 
View on Taylor & Francis
tandfonline.com
61 Citations
Background Citations
10

61 Citations

Peptide-based materials for cancer immunotherapy
TLDR
The role of peptides in regulating the functions of the innate and adaptive immune systems and the impacts of peptide length and formulations on their immunogenicity are described and some critical challenges for translating peptides into large-scale synthesis, safe delivery, and efficient cancer immunotherapy are posed.
Peptide-based combination nanoformulations for cancer therapy.
TLDR
This review focuses on nanodelivery systems for peptide-based combinations with chemo, immuno, radiation and hormone therapy, and gives an overview of the latest therapeutic research being conducted using combination nanoformulations with anticancer peptides, peptide nanocarriers, peptidomimetics, peptides-based hormones and peptide vaccines.
Long-term delivery of protein and peptide therapeutics for cancer therapies
TLDR
This review covers recent advancements in approaches involving conjugated protein nano-formulations as targeting delivery technology for various ailments encompassing mostly cancer treatment options, and significant expansions have been made in forming new generation of antitumor-recombinant proteins.
Current Prospects in Peptide-Based Subunit Nanovaccines.
TLDR
This chapter outlines the recent developments and advances of nano-sized delivery platforms for peptide antigens, including nanoparticles composed of polymers, peptides, lipids, and inorganic materials.
Traceable metallic antigen release for enhanced cancer immunotherapy
TLDR
A traceable nanovaccine based on gold nanocluster-labeled antigens and upconversion nanoparticles (UCNPs) for the treatment of melanoma is synthesized and demonstrated that UCNPs conjugated metallic antigen showed excellent biocompatibility, pH-sensitive and therapeutic effect.
Advanced Approaches of Bioactive Peptide Molecules and Protein Drug Delivery Systems.
TLDR
In the process of investigation, it was found that transdermal route is not posing any challenges of enzymatic degradation, but, still absorption is the limitation as the outer layer of skin acts as a barrier.
Mannose-modified liposome designed for epitope peptide drug delivery in cancer immunotherapy.
Soft and Condensed Nanoparticles and Nanoformulations for Cancer Drug Delivery and Repurpose
TLDR
In this review, recent developments in nano‐delivery and formulation systems based on soft and condensed nanomaterials, as well as their theranostic applications in drug repurpose against cancer are summarized.
Overview and Future Potential of Fast Dissolving Buccal Films as Drug Delivery System for Vaccines.
  • M. Uddin, A. Allon, M. Roni, Samir S Kouzi
  • Biology
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2019
TLDR
This article thoroughly reviewed the possibility of developing a quickly soluble film-based delivery system for vaccine administration and summarized the different types of new vaccines and vaccine formulations and their suitability for use in a film dosage form.
The influence of nanoparticulate drug delivery systems in drug therapy
...
...

References

SHOWING 1-10 OF 104 REFERENCES
Improvement of different vaccine delivery systems for cancer therapy
TLDR
Different vaccine delivery systems for prevention or treatment of cancer, including nanoparticles (NPs), have emerged as effective vaccine adjuvants for infectious diseases and cancer therapy and their clinical applications and the future prospects for cancer vaccine development are discussed.
Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery
TLDR
The biological functionalization of polymeric nanoparticles with a layer of membrane coating derived from cancer cells is reported on, showing that by coupling the particles with an immunological adjuvant, the resulting formulation can be used to promote a tumor-specific immune response for use in vaccine applications.
Polymeric nanoparticles: Promising platform for drug delivery.
Second generation liposomal cancer therapeutics: transition from laboratory to clinic.
  • K. Sen, M. Mandal
  • Biology, Chemistry
    International journal of pharmaceutics
  • 2013
In Vitro Administration of Gold Nanoparticles Functionalized with MUC-1 Protein Fragment Generates Anticancer Vaccine Response via Macrophage Activation and Polarization Mechanism
TLDR
This is the first study to evaluate the anticancer effects of a newly designed nano-biocompound on the complex antigen- processing apparatus of peritoneal macrophages and demonstrates optimization of antigen-presenting process and predominant M1 polarization following exposure GNP-MUC-1.
Ligand-targeted liposome design: challenges and fundamental considerations.
Multifunctional nanoparticles for targeted delivery of immune activating and cancer therapeutic agents.
Lipid-based nanocarriers for oral peptide delivery.
In vivo gold nanoparticle delivery of peptide vaccine induces anti-tumor immune response in prophylactic and therapeutic tumor models.
TLDR
It is found that AuNP-mediated OVA peptide delivery alone, without CpG, is sufficient to promote significant antigen-specific responses, leading to subsequent anti-tumor activity and prolonged survival in both prophylactic and therapeutic in vivo tumor models.
Ligand-directed active tumor-targeting polymeric nanoparticles for cancer chemotherapy.
TLDR
With promise to maximize therapeutic efficacy while minimizing systemic side effects, ligand-mediated active tumor-targeting treatment modality has become an emerging and indispensable platform for safe and efficient cancer therapy.
...
...