Nanoparticle diffusion in sheared cellular blood flow

@article{Liu2019NanoparticleDI,
  title={Nanoparticle diffusion in sheared cellular blood flow},
  author={Zixiang Liu and Jonathan R. Clausen and Rekha Ranjana Rao and Cyrus K. Aidun},
  journal={Journal of Fluid Mechanics},
  year={2019},
  volume={871},
  pages={636 - 667}
}
Using a multiscale blood flow solver, the complete diffusion tensor of nanoparticles (NPs) in sheared cellular blood flow is calculated over a wide range of shear rate and haematocrit. In the short-time regime, NPs exhibit anomalous dispersive behaviors under high shear and high haematocrit due to the transient elongation and alignment of the red blood cells (RBCs). In the long-time regime, the NP diffusion tensor features high anisotropy. Particularly, there exists a critical shear rate… 

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References

SHOWING 1-10 OF 90 REFERENCES

Scaling of shear-induced diffusion and clustering in a blood-like suspension

TLDR
The properties directly related to RBC deformability —stretching and flow orientation— are not sufficient to explain this departure according to the model of Breedveld, pointing to the dominance of collective effects in the suspension.

Shear-induced particle migration and margination in a cellular suspension

We simulate the cross-flow migration of rigid particles such as platelets in a red blood cell (RBC) suspension using the Stokes flow boundary integral equation method. Two types of flow environments

Rheological characterization of cellular blood in shear

Abstract A hybrid lattice-Boltzmann spectrin-link (LB–SL) method is used to simulate dense suspensions of red blood cells (RBCs) for investigating rheological properties of blood. RBC membranes are

Self-diffusion in sheared suspensions

Self-diffusion in a suspension of spherical particles in steady linear shear flow is investigated by following the time evolution of the correlation of number density fluctuations. Expressions are

Self-diffusion in sheared suspensions by dynamic simulation

The behaviour of the long-time self-diffusion tensor in concentrated colloidal dispersions is studied using dynamic simulation. The simulations are of a suspension of monodisperse Brownian hard

Coupling of Navier–Stokes equations with protein molecular dynamics and its application to hemodynamics

TLDR
A new modelling technique is introduced that couples Navier–Stokes equations with protein molecular dynamics to investigate the behaviours of RBC aggregates and their effects on the blood rheology and explains the shear‐rate‐dependence of the blood viscoelastic properties.

Microstructure of strongly sheared suspensions and its impact on rheology and diffusion

The effects of Brownian motion alone and in combination with an interparticle force of hard-sphere type upon the particle configuration in a strongly sheared suspension are analysed. In the limit

Shear-induced platelet margination in a microchannel.

  • Hong ZhaoE. Shaqfeh
  • Physics
    Physical review. E, Statistical, nonlinear, and soft matter physics
  • 2011
TLDR
The lateral migration of platelets in a microchannel is studied numerically where the hydrodynamic interactions between red cells, platelets, and vessel walls are resolved by the Stokes flow boundary integral equations and the lateral migration is shown to be diffusional.
...