Nanoparticle cytotoxicity depends on intracellular solubility: comparison of stabilized copper metal and degradable copper oxide nanoparticles.

@article{Studer2010NanoparticleCD,
  title={Nanoparticle cytotoxicity depends on intracellular solubility: comparison of stabilized copper metal and degradable copper oxide nanoparticles.},
  author={Andreas M Studer and Ludwig K Limbach and Luu Van Duc and Frank Krumeich and Evagelos Kimon Athanassiou and Lukas Gerber and Holger Moch and Wendelin J Stark},
  journal={Toxicology letters},
  year={2010},
  volume={197 3},
  pages={169-74}
}
Metal nanoparticles have distinctly different chemical and physical properties than currently investigated oxides. Since pure metallic nanoparticles are igniting at air, carbon stabilized copper nanoparticles were used as representative material for this class. Using copper as a representative example, we compare the cytotoxicity of copper metal nanoparticles stabilized by a carbon layer to copper oxide nanoparticles using two different cell lines. Keeping the copper exposure dose constant, the… CONTINUE READING

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