Nanoparticle core stability and surface functionalization drive the mTOR signaling pathway in hepatocellular cell lines

@inproceedings{Lunova2017NanoparticleCS,
  title={Nanoparticle core stability and surface functionalization drive the mTOR signaling pathway in hepatocellular cell lines},
  author={Mariia Lunova and Andrey I. Prokhorov and Milan Jirsa and Martin Hof and Agnieszka Olżyńska and Piotr Jurkiewicz and Sarka Kubinova and Oleg Lunov and Alexandr Dejneka},
  booktitle={Scientific Reports},
  year={2017}
}
  • Mariia Lunova, Andrey I. Prokhorov, +6 authors Alexandr Dejneka
  • Published in Scientific Reports 2017
  • Chemistry, Medicine
  • Specifically designed and functionalized nanoparticles hold great promise for biomedical applications. Yet, the applicability of nanoparticles is critically predetermined by their surface functionalization and biodegradability. Here we demonstrate that amino-functionalized polystyrene nanoparticles (PS-NH2), but not amino- or hydroxyl-functionalized silica particles, trigger cell death in hepatocellular carcinoma Huh7 cells. Importantly, biodegradability of nanoparticles plays a crucial role in… CONTINUE READING

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