Nanoparticle-based therapeutic delivery of prohibitin to the colonic epithelial cells ameliorates acute murine colitis.

@article{Theiss2011NanoparticlebasedTD,
  title={Nanoparticle-based therapeutic delivery of prohibitin to the colonic epithelial cells ameliorates acute murine colitis.},
  author={Arianne L. Theiss and Hamed Laroui and Tracy Sitler Obertone and Indrajit Chowdhury and Winston E. Thompson and D. Lynda Merlin and Shanthi V. Sitaraman},
  journal={Inflammatory bowel diseases},
  year={2011},
  volume={17 5},
  pages={
          1163-76
        }
}
BACKGROUND Intestinal epithelial expression of antioxidants and nuclear factor kappa B (NF-κB) contribute to mucosal barrier integrity and epithelial homeostasis, two key events in the pathogenesis of inflammatory bowel disease (IBD). Genetic restoration of intestinal epithelial prohibitin 1 (PHB) levels during experimental colitis reduces the severity of disease through sustained epithelial antioxidant expression and reduced NF-κB activation. To determine the therapeutic potential of restoring… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 28 REFERENCES

Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis.

  • American journal of physiology. Gastrointestinal and liver physiology
  • 2009
VIEW 1 EXCERPT