Nanoparticle-based electrochemical immunosensor for the detection of phosphorylated acetylcholinesterase: an exposure biomarker of organophosphate pesticides and nerve agents.

@article{Liu2008NanoparticlebasedEI,
  title={Nanoparticle-based electrochemical immunosensor for the detection of phosphorylated acetylcholinesterase: an exposure biomarker of organophosphate pesticides and nerve agents.},
  author={Guodong Liu and Jun Wang and Richard C Barry and Catherine E Petersen and Charles A Timchalk and Paul L. Gassman and Yuehe Lin},
  journal={Chemistry},
  year={2008},
  volume={14 32},
  pages={9951-9}
}
A nanoparticle-based electrochemical immunosensor has been developed for the detection of phosphorylated acetylcholinesterase (AChE), which is a potential biomarker of exposure to organophosphate (OP) pesticides and chemical warfare nerve agents. Zirconia nanoparticles (ZrO(2) NPs) were used as selective sorbents to capture the phosphorylated AChE adduct, and quantum dots (ZnS@CdS, QDs) were used as tags to label monoclonal anti-AChE antibody to quantify the immunorecognition events. The… CONTINUE READING
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Toxicology of Organophosphate and Carbamate Compounds

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Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim www.chemeurj.org 9959 FULL PAPER Electrochemical Sensor for Organophosphate Pesticides and Nerve Agents

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