Nanoparticle-based brachytherapy spacers for delivery of localized combined chemoradiation therapy.

@article{Kumar2015NanoparticlebasedBS,
  title={Nanoparticle-based brachytherapy spacers for delivery of localized combined chemoradiation therapy.},
  author={Rajiv Kumar and Jodi E. Belz and Stacey Markovic and Tej Jadhav and William H Fowle and Mark Niedre and Robert A. Cormack and Mike Makrigiorgos and Srinivas Sridhar},
  journal={International journal of radiation oncology, biology, physics},
  year={2015},
  volume={91 2},
  pages={
          393-400
        }
}
PURPOSE In radiation therapy (RT), brachytherapy-inert source spacers are commonly used in clinical practice to achieve high spatial accuracy. These implanted devices are critical technical components of precise radiation delivery but provide no direct therapeutic benefits. METHODS AND MATERIALS Here we have fabricated implantable nanoplatforms or chemoradiation therapy (INCeRT) spacers loaded with silica nanoparticles (SNPs) conjugated containing a drug, to act as a slow-release drug depot… CONTINUE READING
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