Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomy.

@article{Thaxton2009NanoparticlebasedBA,
  title={Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomy.},
  author={C Shad Thaxton and Robert Elghanian and Audrey D Thomas and Savka Ilieva Stoeva and Jae-Seung Lee and Norm D. Smith and Anthony Schaeffer and Helmut Klocker and Christian Bachmayer and Georg Bartsch and Chad A. Mirkin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 44},
  pages={
          18437-42
        }
}
We report the development of a previously undescribed gold nanoparticle bio-barcode assay probe for the detection of prostate specific antigen (PSA) at 330 fg/mL, automation of the assay, and the results of a clinical pilot study designed to assess the ability of the assay to detect PSA in the serum of 18 men who have undergone radical prostatectomy for prostate cancer. Due to a lack of sensitivity, available PSA immunoassays are often not capable of detecting PSA in the serum of men after… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 93 CITATIONS, ESTIMATED 67% COVERAGE

Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine.

  • Advanced drug delivery reviews
  • 2012
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Potential Applications of Nanotechnology in Urological Cancer

  • Front. Pharmacol.
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

FILTER CITATIONS BY YEAR

2009
2019

CITATION STATISTICS

  • 2 Highly Influenced Citations

  • Averaged 5 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Natural history of progression after PSA elevation following radical prostatectomy

CR Pound
  • JAMA
  • 1999
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…