Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomy.

@article{Thaxton2009NanoparticlebasedBA,
  title={Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomy.},
  author={C Shad Thaxton and Robert Elghanian and Audrey D Thomas and Savka Ilieva Stoeva and Jae-Seung Lee and Norm D. Smith and Anthony Schaeffer and Helmut Klocker and Wolfgang Horninger and Gorja Bartsch and Chad A. Mirkin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 44},
  pages={
          18437-42
        }
}
We report the development of a previously undescribed gold nanoparticle bio-barcode assay probe for the detection of prostate specific antigen (PSA) at 330 fg/mL, automation of the assay, and the results of a clinical pilot study designed to assess the ability of the assay to detect PSA in the serum of 18 men who have undergone radical prostatectomy for prostate cancer. Due to a lack of sensitivity, available PSA immunoassays are often not capable of detecting PSA in the serum of men after… CONTINUE READING

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