Nanoparticle Formulation of Brusatol: A Novel Therapeutic Option for Cancers

@inproceedings{Adesina2018NanoparticleFO,
  title={Nanoparticle Formulation of Brusatol: A Novel Therapeutic Option for Cancers},
  author={Simeon K. Adesina},
  year={2018}
}
Objective: Challenges to the use of brusatol for cancer chemotherapy include its reversible and short-lived effect on Nrf2 which is limited to a few hours, its non-selective inhibition of protein synthesis which renders it potentially toxic to non-cancerous cells resulting in adverse effects and poor water solubility. A nanoparticle formulation of brusatol is expected to overcome these challenges and facilitate the clinical use of brusatol. In this proof-of-principle study, a brusatol-loaded… CONTINUE READING

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