Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges

  title={Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges},
  author={J Y Zhou and K Shum and John C. Burnett and John J. Rossi},
RNA interference (RNAi) is an evolutionarily conserved, endogenous process for post-transcriptional regulation of gene expression. Although RNAi therapeutics have recently progressed through the pipeline toward clinical trials, the application of these as ideal, clinical therapeutics requires the development of safe and effective delivery systems. Inspired by the immense progress with nanotechnology in drug delivery, efforts have been dedicated to the development of nanoparticle-based RNAi… CONTINUE READING