Nanoparticle/siRNA-based therapy strategies in glioma: which nanoparticles, which siRNAs?

@article{Aigner2018NanoparticlesiRNAbasedTS,
  title={Nanoparticle/siRNA-based therapy strategies in glioma: which nanoparticles, which siRNAs?},
  author={Achim Aigner and Donat K{\"o}gel},
  journal={Nanomedicine},
  year={2018},
  volume={13 1},
  pages={89-103}
}
Nanomedicines allow for the delivery of small interfering RNAs (siRNAs) that are otherwise barely suitable as therapeutics for inducing RNA interference (RNAi). In preclinical studies on siRNA-based glioma treatment in vivo, various groups of nanoparticle systems, routes of administration and target genes have been explored. Targeted delivery by functionalization of nanoparticles with a ligand for crossing the blood-brain barrier and/or for enhanced target cell transfection has been described… CONTINUE READING